In vitro and in vivo antimycobacterial activity of antiinflammatory drug, diclofenac sodium.
Indian J Exp Biol
;
2004 Sep; 42(9): 922-7
Artículo
en Inglés
| IMSEAR
| ID: sea-60401
ABSTRACT
The non-steroidal antiinflammatory drug diclofenac sodium exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This agent was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 microg/ml concentration. When tested in vivo, diclofenac, injected at 10 mg/kg body weight of a Swiss strain of white mice, could significantly protect them when challenged with a 50 median lethal dose of M. tuberculosis H37 Rv102. According to Chi-square test, the in vivo data were highly significant (P<0.01).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Masculino
/
Pruebas de Sensibilidad Microbiana
/
Antiinflamatorios no Esteroideos
/
Diclofenaco
/
Animales
/
Ratones
/
Antibacterianos
/
Mycobacterium
/
Infecciones por Mycobacterium
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2004
Tipo del documento:
Artículo
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