Effect of DENA induced hepatocarcinogenesis on neuroendocrine levels in male rats.
Indian J Exp Biol
;
2008 Jul; 46(7): 498-504
Artículo
en Inglés
| IMSEAR
| ID: sea-60461
ABSTRACT
Hepatocarcinogenesis was induced in Sprague Dawley rats by injecting diethylnitrosamine (DENA); 150 mg/kg body weight, ip, a well known liver carcinogen and a mutagenic agent. Concurrent with the induction of hepatocarcinoma, psychological stress was also elicited from the changes in brain neurotransmitters. Noradrenaline and dopamine, the neurotransmitters of sympathetic system were estimated from the whole brain and corresponding hormones T3, T4 and prolactin were estimated from the blood of such rats. The neuroendocrine cascade and the marker enzyme gamma glutamyl transferase were estimated at 7, 14, 21 and 30 weeks. A direct relationship between noradrenaline, T3 and T4 and a reciprocal relationship between dopamine and prolactin were observed, which may be correlated to the carcinogenic effect of DENA.
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IMSEAR (Asia Sudoriental)
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Inglés
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Indian J Exp Biol
Año:
2008
Tipo del documento:
Artículo
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