Effects of paraquat on anti-oxidant system in rats.
Indian J Exp Biol
;
2007 May; 45(5): 432-8
Artículo
en Inglés
| IMSEAR
| ID: sea-60515
ABSTRACT
The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione levels in blood cells, liver, lung and kidney tissues decreased in a dose and time dependent manner. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase increased in paraquat exposure. Malondialdehyde formation also increased in a dose and time dependent manner. The alterations of anti-oxidant system particularly glutathione can be utilized as biomarkers during management of paraquat poisoning.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Paraquat
/
Ratas
/
Superóxido Dismutasa
/
Masculino
/
Peroxidación de Lípido
/
Catalasa
/
Ratas Wistar
/
Estrés Oxidativo
/
Relación Dosis-Respuesta a Droga
/
Eritrocitos
Tipo de estudio:
Estudios de evaluación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS