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Possible role of citalopram and desipramine against sleep deprivation-induced anxiety like-behavior alterations and oxidative damage in mice.
Indian J Exp Biol ; 2008 Nov; 46(11): 770-6
Artículo en Inglés | IMSEAR | ID: sea-60604
ABSTRACT
Sleep is an essential physiological process for maintaining physical, mental, and emotional health. Sleep deprivation and associated disorders like depression and anxiety are one of the major problems now-days. The present study was designed to explore the neuroprotecitve effect of citalopram and desipramine on 72 hr sleep deprivation-induced behavioral alterations and oxidative damage in mice. Various behavioral tests (plus maze, zero maze, mirror chamber, actophotometer), body weight followed by oxidative parameters (malondialdehyde level, glutathione, catalase, nitrite and protein) were assessed. Treatment with citalopram (5 and 10 mg/kg, ip) and desipramine (10 and 20 mg/kg, ip) for 5 days significantly improved locomotor activity, anti-anxiety like behavior in all paradigms tasks (mirror chamber, plus maze, zero maze) as compared to control (72 hr sleep-deprived). Biochemically, citalopram and desipramine treatment significantly restored depleted reduced glutathione, catalase activity, attenuated raised lipid peroxidation and nitrite level as compared to control (72 hr sleep-deprived) animals. Results of present study suggest that citalopram (5 and 10mg/kg, ip) and desipramine (10 and 20 mg/kg, ip) have neuroprotective effect against sleep deprivation-induced behavior alteration and oxidative damage in mice.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Sueño / Privación de Sueño / Conducta Animal / Encéfalo / Citalopram / Inhibidores Selectivos de la Recaptación de Serotonina / Estrés Oxidativo / Fármacos Neuroprotectores / Aprendizaje por Laberinto Idioma: Inglés Revista: Indian J Exp Biol Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Sueño / Privación de Sueño / Conducta Animal / Encéfalo / Citalopram / Inhibidores Selectivos de la Recaptación de Serotonina / Estrés Oxidativo / Fármacos Neuroprotectores / Aprendizaje por Laberinto Idioma: Inglés Revista: Indian J Exp Biol Año: 2008 Tipo del documento: Artículo