Central inhibitory effect of Moringa oleifera root extract: possible role of neurotransmitters.
Indian J Exp Biol
;
2003 Nov; 41(11): 1279-84
Artículo
en Inglés
| IMSEAR
| ID: sea-61125
ABSTRACT
Effect of chronic treatment of standardized aqueous extract of Moringa oleifera (MO) root (100, 200, 300, 350, 400, 450 mg/kg; po) on penicillin (PCN) induced convulsion, locomotor behaviour, brain serotonin (5-HTT), dopamine (DA) and norepinephrine (NE) level was studied in Holtzman strain adult albino rats. The result revealed that pretreatment with MO inhibited PCN-induced seizure and markedly reduced locomotor activity. Chronic treatment with MO significantly increased the 5-HT and decreased the DA level in cerebral cortex (CC), midbrain (MB), caudate nucleus (CN) and cerebellum (CB). NE level was significantly decreased in CC but no appreciable change was observed in MB, CB and CN. Thus the central inhibitory effect of MO is discussed in the light of the disturbed balance between 5-HT, DA and NE.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Penicilinas
/
Ratas
/
Convulsiones
/
Conducta Animal
/
Encéfalo
/
Química Encefálica
/
Femenino
/
Masculino
/
Extractos Vegetales
/
Dopamina
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2003
Tipo del documento:
Artículo
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