Tamoxifen increases the proliferation of human endometrial stromal cells in in vitro. A model for evaluation of endometrial hyperplasia.
Indian J Exp Biol
;
1995 Dec; 33(12): 977-9
Artículo
en Inglés
| IMSEAR
| ID: sea-61182
ABSTRACT
Tamoxifen given for breast cancer therapy, has a complex and an unclear action on the endometrium. A large number of literatures has attributed the proliferous changes in the endometrium caused by tamoxifen (Tam). No report has appeared on the endometrial cellular changes induced by Tam. The present study shows a significant (P < 0.001) increase in the proliferative activity due to Tam in endometrial stromal cells over control and estradiol (E2). This in vitro model is useful for the study of the hyperplasic effect of Tam at the cellular level.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Tamoxifeno
/
Femenino
/
Humanos
/
División Celular
/
Células del Estroma
/
Hiperplasia Endometrial
/
Endometrio
/
Estudios de Evaluación como Asunto
/
Modelos Biológicos
Tipo de estudio:
Estudio diagnóstico
/
Estudios de evaluación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1995
Tipo del documento:
Artículo
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