Effect of chronic treatment with losartan on streptozotocin induced diabetic rats.
Indian J Exp Biol
;
2002 Jan; 40(1): 31-4
Artículo
en Inglés
| IMSEAR
| ID: sea-61398
ABSTRACT
Treatment of rats with streptozotocin (STZ, 45mg/kg, i.v.,single dose) produced cardinal symptoms of diabetes mellitus including hyperglycemia, hypoinsulinemia and increase in blood pressure. Treatment with losartan--an angiotensin (AT1) receptor antagonist, 2 mg/kg, po for 6 weeks decreased the blood glucose levels by 16.5%. There was 190% increase in AUCglucose and 59.4% decrease in AUCinsulin in STZ-diabetic rats as compared to control rats. Treatment with losartan caused slight decrease in AUCglucose and slight increase in AUCinsulin. There was no significant difference in insulin sensitivity (K(ITT)) index of STZ-diabetic group as compared to control. Losartan treatment failed to alter these levels significantly. Serum cholesterol and creatinine levels were found to be increased significantly in STZ-diabetic rats. Treatment with losartan significantly prevented the rise in cholesterol and creatinine levels by 20.1 and 81% respectively. The results suggest that losartan produces some beneficial effects in STZ-diabetic rats.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Glucemia
/
Presión Sanguínea
/
Femenino
/
Colesterol
/
Ratas Wistar
/
Área Bajo la Curva
/
Losartán
/
Creatinina
/
Diabetes Mellitus Experimental
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2002
Tipo del documento:
Artículo
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