Receptor-operated calcium-channels in isolated rabbit jejunum.
Indian J Exp Biol
;
1992 Feb; 30(2): 107-9
Artículo
en Inglés
| IMSEAR
| ID: sea-61500
ABSTRACT
Calcium channels were studied in isolated spontaneously rhythmic rabbit jejunum using the muscarinic agonist carbachol as stimulant. Carbachol failed to produce the characteristic phasic and tonic components of smooth muscle contractions. A variety of chemically distinct calcium antagonists, viz. bepridil, diltiazem, isradipine (PN 200-110), nifedipine, and verapamil, non-competitively inhibited the contractions. Diltiazem was most potent (-logIC50 = 8.30) and bepridil least potent (-logIC50 = 6.19) in inhibiting the contractions. The findings conclude with the presence of pharmacologically distinct receptor-operated calcium-channels, besides the potential-dependent calcium-channels, in the rabbit jejunum.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Conejos
/
Carbacol
/
Bloqueadores de los Canales de Calcio
/
Canales de Calcio
/
Relación Dosis-Respuesta a Droga
/
Yeyuno
/
Animales
/
Contracción Muscular
/
Músculo Liso
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1992
Tipo del documento:
Artículo
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