Cerebellar granule cell membranes and glutamate mediates transactivation of glutamine synthetase promoter.
Indian J Exp Biol
;
1997 Feb; 35(2): 123-7
Artículo
en Inglés
| IMSEAR
| ID: sea-61700
ABSTRACT
Potential region of glutamine synthetase promoter driving astrocyte-specific transactivation, mediated by cerebellar granule cell membrane and glutamate has been identified by deletion analysis of promoter and transient transfection. The promoter region from -420 to -765 was found to be potentially important for this transactivation. These results provided further evidence for importance of neuronal-glial and glutamate-glial interactions in regulation of glial gene expression.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Células Tumorales Cultivadas
/
Activación Transcripcional
/
Cerebelo
/
Astrocitos
/
Mutagénesis Sitio-Dirigida
/
Regiones Promotoras Genéticas
/
Ácido Glutámico
/
Gránulos Citoplasmáticos
/
Glutamato-Amoníaco Ligasa
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1997
Tipo del documento:
Artículo
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