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H2O2-induced lipid peroxidation in mitochondria of pulmonary vascular smooth muscle tissue and its modification by DFO, DMTU and DIDS.
Indian J Exp Biol ; 1996 Dec; 34(12): 1220-3
Artículo en Inglés | IMSEAR | ID: sea-61740
ABSTRACT
Treatment of bovine pulmonary artery smooth muscle tissue mitochondria with H2O2 stimulated iron release, hydroxyl radical (OH) production and lipid peroxidation. Pretreatment of mitochondria with deferoxamine (DFO) and dimethyl thiourea (DMTU) prevented OH production and markedly reduced lipid peroxidation without appreciably altering iron release caused by H2O2. Simultaneous treatment of either DFO or DMTU with H2O2 significantly reduced lipid peroxidation and also prevented OH production without causing marked decrease in iron release. In contrast, addition of DFO or DMTU even 2 min after treatment of the mitochondria with H2O2 did not significantly altered iron release, OH production and lipid peroxidation. Pretreatment of the mitochondria with 4,4'-dithiocyano-2,2'-disulfonic acid stilbene (DIDS) markedly reduced lipid peroxidation without appreciably altering the increase in OH production and iron release caused by H2O2.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Tiourea / Bovinos / Peroxidación de Lípido / Circulación Pulmonar / Depuradores de Radicales Libres / Ácido 4,4'-Diisotiocianostilbeno-2,2'-Disulfónico / Deferoxamina / Peróxido de Hidrógeno / Animales / Mitocondrias Musculares Idioma: Inglés Revista: Indian J Exp Biol Año: 1996 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Tiourea / Bovinos / Peroxidación de Lípido / Circulación Pulmonar / Depuradores de Radicales Libres / Ácido 4,4'-Diisotiocianostilbeno-2,2'-Disulfónico / Deferoxamina / Peróxido de Hidrógeno / Animales / Mitocondrias Musculares Idioma: Inglés Revista: Indian J Exp Biol Año: 1996 Tipo del documento: Artículo