Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat.
Indian J Exp Biol
;
1998 Oct; 36(10): 1020-2
Artículo
en Inglés
| IMSEAR
| ID: sea-62736
ABSTRACT
Interactive effects of gossypol and chloroquine as determined by activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and liver lactate dehydrogenase (LDH), alkaline phosphatase (ALK-pase), glucose-6-phosphatase (G-6-pase) and cholesterol level were investigated in rats. Administration of gossypol for eight weeks, at a concentration of 20 mg per kg body wt. per day with or without chloroquine had no effect on the serum enzymes and glucose-6-phosphatase activities. When chloroquine at a concentration of 5 mg per kg body wt. thrice a week was administered alone, there was a marked decrease in total protein content and ALK-pose activities, while a significant increase in LDH activity was observed. Administration of either gossypol or chloroquine decreased the level of cholesterol. A greater decrease was recorded when both were given together. It is suggested that gossypol can be employed as a male contraceptive among malaria-infected populations.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Masculino
/
Gosipol
/
Cloroquina
/
Ratas Wistar
/
Interacciones Farmacológicas
/
Hígado
/
Animales
/
Antimaláricos
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1998
Tipo del documento:
Artículo
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