In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol.
Indian J Exp Biol
;
2005 Mar; 43(3): 291-3
Artículo
en Inglés
| IMSEAR
| ID: sea-62942
ABSTRACT
Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Intercambio de Cromátides Hermanas
/
Peso Corporal
/
Daño del ADN
/
Femenino
/
Células de la Médula Ósea
/
Aberraciones Cromosómicas
/
Anticonceptivos Sintéticos Orales
/
Linestrenol
/
Animales
/
Ratones
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2005
Tipo del documento:
Artículo
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