Segregation of acrocentric chromosome association in familial dicentric Robertsonian translocation t(14p;22p), aneuploidy (trisomy-21) and heteromorphism.
Indian J Exp Biol
;
1990 Jun; 28(6): 511-5
Artículo
en Inglés
| IMSEAR
| ID: sea-62960
ABSTRACT
The frequency and types of acrocentric chromosome association were quantitatively analysed in a Down syndrome child with unusual karyotype, 46, XX, -14, -22, t dic (14p;22p), +21, 21S+. Father and 4 sibs were heterozygous carriers for t dic (14p;22p). The variant 21S+ was inherited from the mother. The occurrence of translocation and trisomy in the same individual is extremely rare. Acrocentric chromosome association was analysed in this interesting family to understand the interrelationship of acrocentric chromosome association, Robertsonian translocation and heteromorphism, as possible predisposing factors for nondisjunction. Our findings suggest that acrocentric chromosome association is a heritable and nonrandom phenomenon. Heterozygous carriers for translocations and variants are likely to be at increased risk of nondisjunction. Long term family studies will enable to ascertain the causal-relationship of these factors more precisely.
Texto completo:
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Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Linaje
/
Translocación Genética
/
Cromosomas Humanos Par 14
/
Cromosomas Humanos Par 22
/
Femenino
/
Humanos
/
Masculino
/
Síndrome de Down
/
Heterocigoto
/
Cariotipificación
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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