Role of kappa opioid receptors during stress responsiveness in rats.
Indian J Exp Biol
;
1993 Feb; 31(2): 116-9
Artículo
en Inglés
| IMSEAR
| ID: sea-63017
ABSTRACT
Effects of kappa opioid agonist, ketocyclazocine (KCZ) and its antagonist, M(r) 2266, were evaluated on some stress responses in rats. KCZ (1 or 10 mg/kg, ip) dose-dependently attenuated cold restraint stress (CRS)-induced gastric ulcer formation. Similar gastric cytoprotection was also seen with KCZ (1 or 10 micrograms/rat, icv). Pretreatment of rats with M(r) 2266 (0.3 mg/kg, ip) clearly antagonized the ulceroprotective effects of both ip and icv KCZ. KCZ effects on the gastric mucosa during CRS were also reduced by naltrexone (5 mg/kg, ip) pretreatment. KCZ (1 or 10 mg/kg, ip) also attenuated the plasma corticosterone response to CRS and these effects were blocked by M(r) 2266 (0.3 mg/kg) pretreatment. These results indicate kappa opioid receptor involvement during stress reactions and also suggest possible opioidergic interactions during CRS.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Úlcera Gástrica
/
Estrés Fisiológico
/
Benzomorfanos
/
Masculino
/
Corticosterona
/
Etilcetociclazocina
/
Ratas Wistar
/
Receptores Opioides kappa
/
Animales
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1993
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS