Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.
Indian J Exp Biol
;
1994 Oct; 32(10): 718-23
Artículo
en Inglés
| IMSEAR
| ID: sea-63040
ABSTRACT
A new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Masculino
/
Agonistas del GABA
/
Evaluación Preclínica de Medicamentos
/
Ácido gamma-Aminobutírico
/
Analgésicos
/
Animales
/
Ratones
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1994
Tipo del documento:
Artículo
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