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Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent.
Indian J Exp Biol ; 1994 Oct; 32(10): 718-23
Artículo en Inglés | IMSEAR | ID: sea-63040
ABSTRACT
A new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Masculino / Agonistas del GABA / Evaluación Preclínica de Medicamentos / Ácido gamma-Aminobutírico / Analgésicos / Animales / Ratones Idioma: Inglés Revista: Indian J Exp Biol Año: 1994 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Masculino / Agonistas del GABA / Evaluación Preclínica de Medicamentos / Ácido gamma-Aminobutírico / Analgésicos / Animales / Ratones Idioma: Inglés Revista: Indian J Exp Biol Año: 1994 Tipo del documento: Artículo