Genetic alterations in cervical cancer.
Indian J Exp Biol
;
2003 Aug; 41(8): 789-96
Artículo
en Inglés
| IMSEAR
| ID: sea-63227
ABSTRACT
In the pathogenesis of cervical cancer the role of human papillomavirus (HPV) infection is well established. However, other than HPV infection the genetics of cervical cancer remains poorly understood. In the pathogenesis of cervical cancel three major factors are involved, two of which are related to the presence of HPV and the third is the recurrent genetic alterations not linked to HPV infection. Several chromosomal regions with recurrent loss of heterozygosity (LOH) in cervical cancer have been identified. However; the putative tumor suppressor genes located in these chromosomal locations are yet to be identified. Recurrent amplifications have been mapped to the short arm of chromosome 3 in invasive cancer. Microsatellite instability and mutator phenotype do not play a major role in cervical carcinogenesis. As in other cancers, cervical cancer too requires the accumulation of genetic alterations for carcinogenesis to occur. Identification of these alterations could help to provide a better understanding of the disease and thus improve treatment.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Papillomaviridae
/
Femenino
/
Humanos
/
ADN Viral
/
Neoplasias del Cuello Uterino
/
Factores de Riesgo
/
Cromosomas Humanos
/
Mutación Puntual
/
Pérdida de Heterocigocidad
/
Infecciones por Papillomavirus
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
2003
Tipo del documento:
Artículo
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