Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity.
Indian J Exp Biol
;
1996 Sep; 34(9): 845-7
Artículo
en Inglés
| IMSEAR
| ID: sea-63320
ABSTRACT
Whole body irradiation of rats (10 Gy as five fractions) found to produce lung fibrosis within 2 months as seen from increased lung collagen hydroxyproline and histopathology. Oral administration of antioxidants curcumin, ellagic acid, bixin and alpha-tocopherol at a concentration 200 mumole/kg body weight significantly reduced the lung collagen hydroxyproline in these animals. In serum and liver lipid peroxidation which were found to be increased by irradiation was reduced significantly by antioxidant treatment. The liver superoxide dismutase and glutathione peroxidase activity were also found to be increased and catalase activity decreased in irradiated control. Superoxide dismutase activity reduced significantly by antioxidant treatment while catalase activity was found to be increased with alpha-tocopherol treatment. The increased frequency of micronucleated polychromatic erythrocytes after whole body irradiation of mice was found to be significantly reduced with antioxidants.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fibrosis Pulmonar
/
Traumatismos Experimentales por Radiación
/
Protectores contra Radiación
/
Ratas
/
Masculino
/
Peroxidación de Lípido
/
Carotenoides
/
Ratas Wistar
/
Curcumina
/
Ácido Elágico
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1996
Tipo del documento:
Artículo
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