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Adrenergic influence of uterine muscle contractions stimulated by a glycoside from the root of Dalbergia saxatilis.
Indian J Exp Biol ; 1999 Apr; 37(4): 350-4
Artículo en Inglés | IMSEAR | ID: sea-63397
ABSTRACT
The mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by moderate doses of isoprenaline (1.80 nmol-0.40 mumol) and salbutamol (0.13-25 mumol). Adrenaline (9.10 nmol) also caused a reversible decrease (92.6%; P < 0.01) in myometrial contraction stimulated by this glycoside (0.24 mg/ml). Uterine muscle responses to dalsaxin (0.24 mg/ml) were enhanced by the beta-adrenergic receptor antagonist, propranolol, in a dose related manner. Atipamezole (1.50 ng/ml) but not prazosin (7.72 nmol-15.60 nmol) substantially reduced (80%; P < 0.01) myometrial contractions induced by this uterine spasmogen. The results suggest that dalsaxin enhances uterine muscle contraction by stimulating post junctional alpha 2-adrenergic receptors, presumably by inhibiting plasma membrane adenylate cyclase system and its associated increase in intracellular cAMP content.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Plantas Medicinales / Ratas / Contracción Uterina / Femenino / Ratas Wistar / Agonistas alfa-Adrenérgicos / Antagonistas Adrenérgicos alfa / Raíces de Plantas / Agonistas Adrenérgicos beta / Fabaceae Idioma: Inglés Revista: Indian J Exp Biol Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Plantas Medicinales / Ratas / Contracción Uterina / Femenino / Ratas Wistar / Agonistas alfa-Adrenérgicos / Antagonistas Adrenérgicos alfa / Raíces de Plantas / Agonistas Adrenérgicos beta / Fabaceae Idioma: Inglés Revista: Indian J Exp Biol Año: 1999 Tipo del documento: Artículo