Effect of nutritional status on mutagenicity of urine excreted by rats treated with standard/experimental carcinogens.
Indian J Exp Biol
;
1990 Aug; 28(8): 711-3
Artículo
en Inglés
| IMSEAR
| ID: sea-63427
ABSTRACT
Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutagenic activity of urine or various treated groups was in the order deficient diet greater than standard laboratory diet greater than nutritionally sufficient diet. Present results confirmed the earlier observations that nutritionally deficient animals are likely to have more exposure to mutagenic metabolites that are generated by increased phase I enzymes and decreased detoxification system.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Deficiencia de Proteína
/
Ratas
/
Ratas Endogámicas
/
Salmonella typhimurium
/
Deficiencia de Vitamina A
/
Deficiencia de Vitamina B
/
Masculino
/
Carcinógenos
/
Biotransformación
/
Inactivación Metabólica
Idioma:
Inglés
Revista:
Indian J Exp Biol
Año:
1990
Tipo del documento:
Artículo
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