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Factors predicting in-hospital mortality in patients with cirrhosis hospitalized with gastro-esophageal variceal hemorrhage.
Artículo en Inglés | IMSEAR | ID: sea-63695
ABSTRACT

AIM:

To identify factors at the time of admission that predict in-hospital mortality in patients with gastro-esophageal variceal hemorrhage.

METHODS:

Case records of patients admitted with gastro-esophageal variceal hemorrhage between January 1998 and October 2003 were retrospectively analyzed. Relevant clinical and laboratory parameters and their relationship to mortality, were studied. Clinical parameters assessed included Child-Pugh class, ascites, portosystemic encephalopathy (PSE) and occurrence of rebleed within 24 hours of esophago-gastroduodenoscopy. The laboratory parameters assessed were hemoglobin, prothrombin time, serum bilirubin, creatinine and albumin.

RESULTS:

Of the 343 patients admitted during the study period, 30 (8.7%) died in hospital. Serum bilirubin (2.4 versus 1.6 mg/dL) and serum creatinine (2.1 vs 1.1 mg/dL) levels were higher among non-survivors than among survivors. Non-survivors were also more likely to suffer from PSE (53%) than survivors (17%), while re-bleeding within 24 hours of endoscopy occurred in 40% and 5% of these groups, respectively. On multivariate analysis, serum creatinine > 1.5 mg/dL at the time of admission (p < 0.001), serum bilirubin > 3 mg/dL (p < 0.001), presence of PSE (p = 0.003) and rebleed within 24 hours of endoscopy (p < 0.001) were significant predictors of mortality.

CONCLUSION:

Serum creatinine and bilirubin levels, presence of PSE and re-bleeding within 24 hours of initial endoscopy are independent predictors of mortality in patients with gastro-esophageal variceal bleeding.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pruebas de Coagulación Sanguínea / Femenino / Humanos / Masculino / Várices Esofágicas y Gástricas / Factores de Riesgo / Mortalidad Hospitalaria / Hemorragia Gastrointestinal / Cirrosis Hepática / Pruebas de Función Hepática Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Idioma: Inglés Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Pruebas de Coagulación Sanguínea / Femenino / Humanos / Masculino / Várices Esofágicas y Gástricas / Factores de Riesgo / Mortalidad Hospitalaria / Hemorragia Gastrointestinal / Cirrosis Hepática / Pruebas de Función Hepática Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Idioma: Inglés Año: 2006 Tipo del documento: Artículo