Multidrug resistance 1 gene expression in Indian patients with gastric carcinoma.
Artículo
en Inglés
| IMSEAR
| ID: sea-63780
ABSTRACT
BACKGROUND:
Gastric carcinoma is frequently refractory to chemotherapy. The multidrug resistance 1 gene (MDR1) encodes for a protein (p-glycoprotein) that functions as a drug efflux pump and thus contributes to resistance to chemotherapeutic agents.METHODS:
We studied gastric tissues from 28 patients with gastric cancer for MDR1 expression, using immunohistochemistry.RESULTS:
Sixteen (57%) of 28 cases showed MDR1 expression. Sections of normal mucosa away from the tumor showed perinuclear staining for MDR1 in surface epithelial cells, whereas tumor cells showed diffuse cytoplasmic positivity.CONCLUSIONS:
Over one half of gastric carcinoma specimens at our center show MDR1 gene expression.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Neoplasias Gástricas
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Inmunohistoquímica
/
Expresión Génica
/
Estudios Seroepidemiológicos
/
Genes MDR
/
India
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS