Immunogenicity and reactogenicity of indigenously produced MMR vaccine.
Indian Pediatr
;
1995 Sep; 32(9): 983-8
Artículo
en Inglés
| IMSEAR
| ID: sea-6401
ABSTRACT
OBJECTIVES:
To study immunogenicity and reactogenicity of indigenously produced MMR vaccine and to assess the booster effect of MMR immunization on measles seroconversion.DESIGN:
A longitudinal follow up.SETTING:
Hospital based and home follow up, as required.SUBJECTS:
89 children already immunized for measles, between 15 to 24 months of age for immunogenic evaluation and 866 subjects for the reactogenic component.METHODS:
Prevaccination and postvaccination samples collected one and four weeks after vaccination were studied by ELISA for IgG and IgM antibodies against the three diseases. A clinical follow up of immunized children was done at 3 days, 7 days, 6 weeks and 6 months after immunization.RESULTS:
IgG positivity 4 weeks after immunization rose from 75% to 100% for measles, from 12% to 92% for mumps, and from 13% to 99% for rubella. Only mild side effects including pain and swelling in 37 (4.3%) cases, mild fever in 51 (5.9%) cases, cough in 40 (4.6%) cases and a transient rash in 7 (0.8%) cases were observed.CONCLUSIONS:
The indigenously manufactured MMR vaccine has an excellent immunogenicity and low reactogenicity with a booster effect for measles seroconversion in children already immunized for this disease.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Rubéola (Sarampión Alemán)
/
Femenino
/
Humanos
/
Masculino
/
Ensayo de Inmunoadsorción Enzimática
/
Vacuna Antisarampión
/
Vacuna contra la Parotiditis
/
Vacuna contra la Rubéola
/
Vacunas Virales
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
1995
Tipo del documento:
Artículo
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