Autoimmune hepatitis: a study of 50 patients.
Artículo
en Inglés
| IMSEAR
| ID: sea-64174
ABSTRACT
INTRODUCTION:
Autoimmune hepatitis (AIH) is a well-defined entity in the West but there are sparse Indian data on this disease.AIM:
To study the clinical profile and response to treatment of Indian patients with AIH.METHODS:
This is a part retrospective and part prospective study of 50 patients (median age 48 years, range 11-82; 43 women) seen between 1995 to 2001, diagnosed to have AIH as per the revised scoring system. Clinical and laboratory profile, response to treatment, and complications of treatment were analyzed.RESULTS:
AIH accounted for 6% of all patients with liver disease seen during the period. The presenting symptoms were gastrointestinal in 43 and non-gastrointestinal in 7, with median symptom duration of 6 months (range 2 weeks to 40 years). Forty patients (80%) had chronic liver disease. Associated illnesses were present in 28 patients. Twenty-six patients were classified as definite and the rest as probable AIH. Forty-nine patients had Type 1 AIH. Five patients had overlap syndrome. Forty-five patients (90%) received immunosuppressive therapy. Twelve of 18 patients receiving only prednisolone and 21 of 27 patients receiving prednisolone and azathioprine combination responded. Thirteen (26%) patients had therapy-related complications (infectious 5, non infectious 8) with two treatment-related deaths.CONCLUSION:
Type 1 AIH was the predominant type of AIH. The majority of patients with AIH presented with chronic liver disease. There was good response to immunosuppressive therapy. Therapy-related complications occurred in one-fourth of patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Anciano de 80 o más Años
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Niño
/
Estudios Prospectivos
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Adolescente
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Aged80
País/Región como asunto:
Asia
Idioma:
Inglés
Año:
2003
Tipo del documento:
Artículo
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