Experimental model of obstructive jaundice in mongrel dog: study of subsequent pathological changes in liver.
Artículo
en Inglés
| IMSEAR
| ID: sea-64542
ABSTRACT
BACKGROUND:
Attempts at creating an experimental model of obstructive jaundice in large animals have been unsuccessful because of frequent fistulization of the ligated bile duct.OBJECTIVES:
To produce a model of obstructive jaundice in mongrel dogs and to study subsequent serial pathological changes in the liver.METHODS:
Four techniques were evaluated in four dogs to produce obstructive jaundice. After creation of a successful model, subsequent clinical and biochemical outcome and serial pathological changes in the liver were studied in another 14 dogs.RESULTS:
Complete extrahepatic biliary dissection produced a model of persistent obstructive jaundice. Serial histological changes included inflammation and edema in the first 14 days followed by lymphocytic infiltration at 28 days. Fibrosis started by day 7 and resulted in architectural distortion by day 21.CONCLUSION:
An acute, complete and irreversible model of obstructive jaundice can be produced by extrahepatic biliary tree excision and ligation. Serial pathological changes showed acute inflammation, followed by fibrosis and architectural distortion.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Masculino
/
Colestasis
/
Técnicas de Cultivo
/
Modelos Animales de Enfermedad
/
Perros
/
Edema
/
Inflamación
/
Hígado
/
Pruebas de Función Hepática
Idioma:
Inglés
Año:
1997
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS