Mucin histochemistry of esophagus in health and malignancy.
Artículo
en Inglés
| IMSEAR
| ID: sea-64685
ABSTRACT
AIMS:
To study mucin histochemistry of the normal esophagus, esophageal adenocarcinoma, and carcinoma exhibiting glandular and squamous elements, to ascertain the origin of these tumors.METHODS:
Mucin histochemistry was studied in sections of the normal cardioesophageal junction obtained from 25 post-mortem specimens and in 12 mucin-secreting esophageal carcinomas.RESULTS:
The normal submucosal esophageal glands and three adenocarcinomas secreted predominantly sulfomucins; a mixture of neutral and sialomucins was seen in the nine carcinomas with squamous and glandular traits. Barrett's metaplasia was not encountered.CONCLUSIONS:
In the absence of Barrett's metaplasia, esophageal adenocarcinoma probably arises from the submucosal glands, whereas squamous carcinomas with mucin-secreting component could arise from metaplastic change in squamous epithelium, cardiac glands, or multipotent stem cells in the epithelium.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Células Madre
/
Esófago de Barrett
/
Biopsia
/
Humanos
/
Neoplasias Esofágicas
/
Transformación Celular Neoplásica
/
Adenocarcinoma Mucinoso
/
Epitelio
/
Esófago
/
Mucinas
Idioma:
Inglés
Año:
1997
Tipo del documento:
Artículo
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