Spectrum of viral hepatitis in thalassemic children receiving multiple blood transfusions.
Artículo
en Inglés
| IMSEAR
| ID: sea-64968
ABSTRACT
AIM:
To investigate the prevalence of infection with hepatitis viruses in children with thalassemia receiving multiple blood transfusions.METHODS:
Sera from 50 children with thalassemia aged 5-15 years (30 boys), who had each received over 80 units of blood, were evaluated for the presence of markers for hepatitis A virus (HAV; IgG and IgM anti-HAV), hepatitis B virus (HBV; HBsAg, and IgG and IgM anti-HBc), hepatitis C virus (HCV; IgG and IgM anti-HCV, and HCV RNA) and hepatitis E virus (HEV; IgG and IgM anti-HEV). IgM anti-hepatitis D virus (HDV) was looked for only in HBsAg or IgM anti-HBc positive sera.RESULTS:
No child had evidence of recent HAV or HDV infection. IgG anti-HAV was positive in 12 children. One patient had acute HBV infection. Nine patients were HBsAg-positive. HCV infection was present in 15 cases; six of them were HCV RNA positive, and three had superinfection with hepatitis B. Recent HEV infection was present in 5 cases.CONCLUSION:
Thalassemic patients receiving multiple blood transfusions often acquire hepatitis B (20%) and C (30%) infections. Recent hepatitis E infection was documented in 10% in this one-point study.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Talasemia
/
Transfusión Sanguínea
/
Humanos
/
Masculino
/
Niño
/
Preescolar
/
Virus de la Hepatitis B
/
Estudios Transversales
/
Adolescente
/
Virus de la Hepatitis E
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Idioma:
Inglés
Año:
2002
Tipo del documento:
Artículo
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