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Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome.
Artículo en Inglés | IMSEAR | ID: sea-65285
ABSTRACT

BACKGROUND:

Irritable bowel syndrome (IBS) is generally considered to have a psychogenic component in its physiopathology.

AIM:

To study the role of serotonin (5-hydroxytryptamine; 5-HT), monoamine oxidase (MAO) and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS.

METHODS:

5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers (aged 18-25 years; all men) and 57 patients with diarrhea-predominant IBS (30-60 years; all men).

RESULTS:

The concentrations of 5-HT (0.3 [0.04] microg/ mL) and MAO (15.5 [3.2] U/mL), and the anxiety level score (14.4 [2.9]) were significantly higher (p < 0.001) in patients than in healthy volunteers (0.1 [0.02], 6.4 [1.4] and 3.4 [1.2], respectively). These parameters correlated with each other in both patients and volunteers.

CONCLUSIONS:

Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Humanos / Masculino / Biomarcadores / Serotonina / Estadística como Asunto / Adolescente / Enfermedades Funcionales del Colon / Adulto / Diarrea Tipo de estudio: Estudios de evaluación País/Región como asunto: Asia Idioma: Inglés Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ansiedad / Humanos / Masculino / Biomarcadores / Serotonina / Estadística como Asunto / Adolescente / Enfermedades Funcionales del Colon / Adulto / Diarrea Tipo de estudio: Estudios de evaluación País/Región como asunto: Asia Idioma: Inglés Año: 2003 Tipo del documento: Artículo