Helicobacter pylori eradication--evaluation of triple therapy containing omeprazole.
Artículo
en Inglés
| IMSEAR
| ID: sea-65622
ABSTRACT
BACKGROUND:
There is a need to develop alternative regimen(s) for treating Helicobacter pylori infection because of problems of drug compliance, side-effects and resistance with the conventional regimen consisting of bismuth, metronidazole and an antibiotic.AIMS:
To compare prospectively the efficacy of conventional triple therapy (bismuth subcitrate 120 mg QID, amoxycillin 500 mg QID and metronidazole 400 mg TID for 2 weeks with one containing omeprazole (20 mg OD), bismuth subcitrate and amoxycillin (regimen B).METHODS:
Sixty two consecutive patients with H pylori infection associated with antral gastritis and/or duodenal ulcer were randomized to two treatment groups and re- evaluated after completion of 2 weeks of therapy and then after a further 4 weeks for eradication of H pylori, ulcer healing and drug side-effects.RESULTS:
Regimen B resulted in higher H pylori eradication rate as compared to regimen A (76.7% vs 63.3%, better ulcer healing rate (90.9%, vs 70.6%), lesser side-effects (10.0% vs 36.7%) and better drug compliance (100% vs 93.3%). The difference between the two regimens was significant (p < 0.05) only in respect to side-effects.CONCLUSION:
For H pylori eradication, omeprazole, bismuth and amoxycillin combination for 2 weeks is as effective as the conventional therapy and is better tolerated.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Compuestos Organometálicos
/
Factores de Tiempo
/
Omeprazol
/
Femenino
/
Humanos
/
Masculino
/
Estudios Prospectivos
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Adulto
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Idioma:
Inglés
Año:
1996
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS