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Helicobacter pylori eradication--evaluation of triple therapy containing omeprazole.
Artículo en Inglés | IMSEAR | ID: sea-65622
ABSTRACT

BACKGROUND:

There is a need to develop alternative regimen(s) for treating Helicobacter pylori infection because of problems of drug compliance, side-effects and resistance with the conventional regimen consisting of bismuth, metronidazole and an antibiotic.

AIMS:

To compare prospectively the efficacy of conventional triple therapy (bismuth subcitrate 120 mg QID, amoxycillin 500 mg QID and metronidazole 400 mg TID for 2 weeks with one containing omeprazole (20 mg OD), bismuth subcitrate and amoxycillin (regimen B).

METHODS:

Sixty two consecutive patients with H pylori infection associated with antral gastritis and/or duodenal ulcer were randomized to two treatment groups and re- evaluated after completion of 2 weeks of therapy and then after a further 4 weeks for eradication of H pylori, ulcer healing and drug side-effects.

RESULTS:

Regimen B resulted in higher H pylori eradication rate as compared to regimen A (76.7% vs 63.3%, better ulcer healing rate (90.9%, vs 70.6%), lesser side-effects (10.0% vs 36.7%) and better drug compliance (100% vs 93.3%). The difference between the two regimens was significant (p < 0.05) only in respect to side-effects.

CONCLUSION:

For H pylori eradication, omeprazole, bismuth and amoxycillin combination for 2 weeks is as effective as the conventional therapy and is better tolerated.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Compuestos Organometálicos / Factores de Tiempo / Omeprazol / Femenino / Humanos / Masculino / Estudios Prospectivos / Helicobacter pylori / Infecciones por Helicobacter / Adulto Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional Idioma: Inglés Año: 1996 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Compuestos Organometálicos / Factores de Tiempo / Omeprazol / Femenino / Humanos / Masculino / Estudios Prospectivos / Helicobacter pylori / Infecciones por Helicobacter / Adulto Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional Idioma: Inglés Año: 1996 Tipo del documento: Artículo