Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
Indian J Med Sci
;
2009 Jan; 63(1): 13-20
Artículo
en Inglés
| IMSEAR
| ID: sea-67183
ABSTRACT
BACKGROUND:
The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. It is considered as candidate gene for low-penetrance breast cancer susceptibility. Hence the present study aims to discuss the role of CYP1A1 polymorphisms in breast cancer. MATERIALS ANDMETHODS:
A total of 250 breast cancer patients and the same number of healthy age-matched controls were analyzed for the polymorphism of CYP1A1*2 by polymerase chain reaction-restriction fragment length polymorphism.RESULTS:
In the present study, association of CYP1A1*2 (Ile 462Val) polymorphism with breast cancer was studied. Only one breast cancer patient was observed to be homozygous for Val allele but none among controls. The frequency of heterozygous Ile/Val genotype was found to be increased significantly in breast cancer patients (68.1%) as compared to controls (51.0%). Higher frequency of heterozygotes for Val allele was observed among premenopausal breast cancer patients and patients with high BMI, positive for HER2/neu status and advanced stage of the disease in comparison to the corresponding groups. No significant association of CYP1A1*2 polymorphism was observed with occupation, estrogen receptor and progesterone receptor status of breast cancer patients.CONCLUSIONS:
In conclusion, our results suggest a significant correlation between CYP1A1*2 expression and the occurrence of breast cancer.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Polimorfismo Genético
/
Neoplasias de la Mama
/
Femenino
/
Humanos
/
Receptores de Progesterona
/
Receptores de Estrógenos
/
Estudios de Casos y Controles
/
Medición de Riesgo
/
Citocromo P-450 CYP1A2
/
Predisposición Genética a la Enfermedad
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Idioma:
Inglés
Revista:
Indian J Med Sci
Año:
2009
Tipo del documento:
Artículo
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