Effects of amantadine on modification of dopamine dependent behaviours by molindone.
Indian J Med Sci
;
2000 Aug; 54(8): 321-4
Artículo
en Inglés
| IMSEAR
| ID: sea-67835
ABSTRACT
Amantadine, a dopamine agonist is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine dependent-behaviors are reversed by amantadine. Amantadine has also revered molindone-induced inhibition of traction response in mice. Our study indicates that amantadine, like other DA agonists, e.g. amphetamine and apomorphine can antagonize or even reverse the neuroleptic induced dopaminergic behaviors.
Texto completo:
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Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Ratas
/
Ratas Endogámicas
/
Valores de Referencia
/
Especificidad de la Especie
/
Conducta Animal
/
Blefaroptosis
/
Masculino
/
Dopaminérgicos
/
Amantadina
/
Dopamina
Idioma:
Inglés
Revista:
Indian J Med Sci
Año:
2000
Tipo del documento:
Artículo
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