Concurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study.
Indian J Med Sci
;
2007 Mar; 61(3): 135-43
Artículo
en Inglés
| IMSEAR
| ID: sea-68311
ABSTRACT
BACKGROUND:
An elevated serum level of C-reactive protein (CRP) is an independent predictor of coronary artery disease (CAD). Chronic infections have also been implicated in the pathogenesis of CAD.AIMS:
To investigate how concomitant chronic infection and CRP related to electrocardiogram-defined CAD in a general population. SETTING ANDDESIGN:
A population-based cross-sectional study, which was conducted in three Iranian ports in the northern Persian Gulf. MATERIALS ANDMETHODS:
For evaluation of CAD, we used Minnesota coding criteria of a 12-lead resting electrocardiogram in 1,754 subjects, aged 25 years and over, selected by cluster random sampling. Sera were analyzed for IgG antibodies to Chlamydia pneumoniae (C. pneumoniae), Herpes simplex virus type 1 (HSV-1), Helicobacter pylori (H. pylori) and cytomegalovirus (CMV) using ELISA. Measurement of CRP by a high-sensitivity CRP assay was done. STATISTICALANALYSIS:
Multiple logistic regression analysis was used.RESULTS:
None of the infectious agents (CMV, H. pylori, C. pneumoniae and HSV-1) showed a significant association with electrocardiogram-defined CAD after adjusting for sex and age. Elevated CRP levels did not show significant association with electrocardiogram-defined CAD independent of seropositivity to one of the four infectious agents, but concurrent elevated CRP levels (>10.0 mg/L) and anti-C. pneumoniae [OR = 1.68 (CI, 1.24-2.59; P=0.04)], H. pylori [OR = 1.98 (CI, 1.26-3.13; P=0.003)], CMV [OR = 1.66 (CI, 1.10-2.49; P=0.01)] or HSV-1 [OR=1.79 (CI, 1.18-2.72; P=0.006)] IgG antibodies were associated with prevalence of electrocardiogram-defined CAD in the general population, after adjustment for multiple risk factors, including age, sex and the components of the metabolic syndrome.CONCLUSIONS:
Beyond traditional cardiovascular risk factors, concomitant chronic infection and elevated CRP are significantly correlated with electrocardiogram-defined CAD.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Población
/
Enfermedad de la Arteria Coronaria
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Proteína C-Reactiva
/
Biomarcadores
/
Oportunidad Relativa
/
Enfermedad Crónica
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Med Sci
Año:
2007
Tipo del documento:
Artículo
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