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Cyclooxygenase-2 expression in primary and recurrent pterygium.
Indian J Ophthalmol ; 2008 Jul-Aug; 56(4): 279-83
Artículo en Inglés | IMSEAR | ID: sea-69912
ABSTRACT

BACKGROUND:

Pterygia are common, benign, fibrovascular, and infiltrative processes of the corneo-conjunctival junction of unknown pathogenesis. Cyclooxygenase-2 (COX-2) mediates the rate-limiting step in arachidonic acid metabolism. Extensive evidence indicates that the COX-2 prostanoid pathway is involved in inflammation. The aim of the study was to document the immunohistochemical expression of COX-2 in primary and recurrent pterygia. MATERIALS AND

METHODS:

In this study, 21 primary pterygia and 12 recurrent pterygia from subjects undergoing pterygium surgery and six normal corneal-scleral tissue specimens were studied immunohistochemically for COX-2 expression.

RESULTS:

COX-2 was expressed in primary pterygia and recurrent pterygia specimens. There was a statistically significant difference in COX-2 expressions in fibroblasts between primary and recurrent pterygium cases ( P = 0.001). There were statistically significant differences in COX-2 expressions in surface epithelium ( P = 0.028) and stromal inflammatory cells ( P =0.000) between control tissues and primary pterygia tissues. We also detected statistically significant differences in COX-2 expressions in surface epithelium ( P =0.000), stromal fibroblasts P =0.000 (stromal fibroblasts and inflammatory cells), vessels ( P = 0.027) and inflammatory cells ( P =0.001) between control tissues and recurrent pterygia tissues.

CONCLUSIONS:

This is the first study to document the expression of COX-2 in primary and recurrent pterygia. In our opinion after excision of pterygia, fibroblastic proliferation continues and this contributes to recurrence.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Recurrencia / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Pterigion / Técnicas para Inmunoenzimas / Adulto / Epitelio Límite: Aged80 Idioma: Inglés Revista: Indian J Ophthalmol Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Recurrencia / Anciano de 80 o más Años / Anciano / Femenino / Humanos / Masculino / Pterigion / Técnicas para Inmunoenzimas / Adulto / Epitelio Límite: Aged80 Idioma: Inglés Revista: Indian J Ophthalmol Año: 2008 Tipo del documento: Artículo