Efficacy of intraoperative vancomycin in irrigating solutions on aqueous contamination during phacoemulsification.
Indian J Ophthalmol
;
2008 Sep-Oct; 56(5): 399-402
Artículo
en Inglés
| IMSEAR
| ID: sea-70794
ABSTRACT
PURPOSE:
To study the efficacy of adding vancomycin in irrigating solutions, in comparison to topical antibiotic given preoperatively for a day, during phacoemulsification, in reducing the anterior chamber (AC) contamination. SETTINGS ANDDESIGN:
This was a prospective, interventional, hospital-based study. MATERIALS ANDMETHODS:
This was a study involving 400 eyes of 400 paitens, undergoing routine phacoemulsification between January 2004 and June 2006. The patients were non-randomly assigned to two groups Group 1 included 180 patients, who received topical ciprofloxacin eye-drops (four-hourly) for a day preoperatively and Group 2 included 220 patients, who underwent phacoemulsification with vancomycin (20 microg/ml) in the irrigating solution. Anterior chamber aspirate obtained at the end of the surgery was sent for microbial workup. The number of positive cultures in both the groups was determined. STATISTICALANALYSIS:
This was performed using Chi-square test.Results:
Aqueous samples showed microbial growth in 38 (21.1%) out of 180 eyes in Group 1 and in 17 (7.7%) out of 220 eyes in Group 2 ( P = 0.001). Coagulase-negative staphylococcus was the most common organism in both the groups. Aqueous samples from four eyes in group 1 showed multiple organisms, while none of the sample from group 2 showed more than one organism. None of the eyes in either group showed fungal contamination. One patient in Group 1 developed endophthalmitis, and the causative organism was Alcaligenes faecalis. All patients were followed up for a minimum of six months (range 6 to 14 months and mean 9.3 months).CONCLUSION:
Addition of vancomycin in irrigating solutions is more efficacious in reducing AC contamination in comparison to topical antibiotic administered a day preoperatively.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humor Acuoso
/
Infecciones Estafilocócicas
/
Staphylococcus
/
Infección de la Herida Quirúrgica
/
Anciano
/
Femenino
/
Humanos
/
Masculino
/
Vancomicina
/
Infecciones Bacterianas del Ojo
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Ophthalmol
Año:
2008
Tipo del documento:
Artículo
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