Etiology and clinical profile of ambiguous genitalia an overview of 10 years experience.
Indian Pediatr
;
2006 Nov; 43(11): 974-9
Artículo
en Inglés
| IMSEAR
| ID: sea-7095
ABSTRACT
One hundred nine patients presenting with ambiguous genitalia over the past 10 years (year 1995 to 2004) to Pediatric Endocrine Service of our hospital were reviewed. On the basis of clinical and investigative evaluation like hormonal and biochemical estimations, imaging studies, karyotype and invasive techniques like genitoscopy, laproscopy, open exploration and biopsy of gonads when indicated, these cases could be categorised as Genetic females with virilisation or FPH (n = 30 cases, 27.5 % Genetic males undervirilised or MPH (n = 57 cases, 52.3 %), Disorders of gonadal differentiation (n = 11, 10.1 %) Nine patients with gonadal dysgenesis and 2 with true hermaphroditism and the syndromic form of ambiguous genitalia (n = 2, 1.8 %). Congenital adrenal hyperplasia (CAH) was the underlying cause in all cases of FPH, the salt wasting form in 23/30 and simple virilising form in 7. Major categories in MPH group were Androgen insensitivity syndrome in 28 % (16/57) and 5a reductase deficiency in 23% (13/57).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Trastornos del Desarrollo Sexual
/
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
/
Niño
/
Preescolar
/
Estudios Retrospectivos
/
Hiperplasia Suprarrenal Congénita
/
India
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
2006
Tipo del documento:
Artículo
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