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Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study.
Indian J Ophthalmol ; 2001 Sep; 49(3): 173-6
Artículo en Inglés | IMSEAR | ID: sea-70989
ABSTRACT

PURPOSE:

To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer.

METHODS:

A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole.

RESULTS:

Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species.

CONCLUSION:

Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Penicillium / Aspergillus / Femenino / Humanos / Masculino / Infecciones Fúngicas del Ojo / Úlcera de la Córnea / Administración Oral / Estudios Prospectivos / Administración Tópica Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional Idioma: Inglés Revista: Indian J Ophthalmol Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Penicillium / Aspergillus / Femenino / Humanos / Masculino / Infecciones Fúngicas del Ojo / Úlcera de la Córnea / Administración Oral / Estudios Prospectivos / Administración Tópica Tipo de estudio: Ensayo Clínico Controlado / Estudio observacional Idioma: Inglés Revista: Indian J Ophthalmol Año: 2001 Tipo del documento: Artículo