Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study.
Indian J Ophthalmol
;
2001 Sep; 49(3): 173-6
Artículo
en Inglés
| IMSEAR
| ID: sea-70989
ABSTRACT
PURPOSE:
To evaluate the efficacy of topical (1%) and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer.METHODS:
A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27) with superficial involvement were treated with only topical itraconazole (1%) and the other half were treated with both topical and systemic itraconazole.RESULTS:
Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77%) and 12 eyes (23%) did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species.CONCLUSION:
Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Penicillium
/
Aspergillus
/
Femenino
/
Humanos
/
Masculino
/
Infecciones Fúngicas del Ojo
/
Úlcera de la Córnea
/
Administración Oral
/
Estudios Prospectivos
/
Administración Tópica
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Idioma:
Inglés
Revista:
Indian J Ophthalmol
Año:
2001
Tipo del documento:
Artículo
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