Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.
J Health Popul Nutr
;
2007 Dec; 25(4): 465-8
Artículo
en Inglés
| IMSEAR
| ID: sea-719
ABSTRACT
The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Infecciones por Rotavirus
/
Humanos
/
Inmunoglobulinas
/
Distribución Aleatoria
/
Inmunización Pasiva
/
Rotavirus
/
Diarrea
/
Modelos Animales de Enfermedad
/
Yema de Huevo
/
Animales
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Inglés
Revista:
J Health Popul Nutr
Asunto de la revista:
Gastroenterology
/
Nutritional Sciences
/
Public Health
Año:
2007
Tipo del documento:
Artículo
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