'NESTROFT'--an effective screening test for beta thalassemia trait.
Indian Pediatr
;
1997 Aug; 34(8): 702-7
Artículo
en Inglés
| IMSEAR
| ID: sea-7244
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of NESTROFT (Naked Eye Single Tube Red Cell Osmotic Fragility Test) as a screening tool for detection of beta thalassemia trait.DESIGN:
Prospective study.SETTING:
Field camps in various parts of Gujarat and Maharashtra States.METHODS:
A total of 2525 subjects were screened. NESTROFT, complete hemogram including red cell indices and calculation of Mentzer's Fraction (MF) and discriminant functions (DF1-4) were done in all subjects. HbA2 was performed in 830 initial subjects to compute sensitivity, specificity and predictive values for various parameters.RESULTS:
NESTROFT (sensitivity 94.4%), as a single screening parameter was superior to any of the other evaluated parameters individually, besides being cost effective. Mean corpuscular volume (MCV) < 80 fl followed NESTROFT closely (sensitivity 93.7; p > 0.05). MCV < 75 fl had a significantly (p < 0.001) lower sensitivity (87.3%) in comparison to both of these parameters. In contrast, MF, DF1, DF2, DF3 and DF4 did not meet the requirements of a good screening test with sensitivity values of 66.2%, 54.9%, 47.2%, 64.1% and 55.6%, respectively. NESTROFT in combination with MCV < 80 fl proved 100% sensitive. However, the combination was not cost effective.CONCLUSION:
NESTROFT is a sensitive, cost effective, rapid and reliable screening test for detection of beta thalassemia trait in a population.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fragilidad Osmótica
/
Femenino
/
Humanos
/
Masculino
/
Niño
/
Tamizaje Masivo
/
Valor Predictivo de las Pruebas
/
Estudios Prospectivos
/
Sensibilidad y Especificidad
/
Adolescente
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio de tamizaje
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian Pediatr
Año:
1997
Tipo del documento:
Artículo
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