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'NESTROFT'--an effective screening test for beta thalassemia trait.
Indian Pediatr ; 1997 Aug; 34(8): 702-7
Artículo en Inglés | IMSEAR | ID: sea-7244
ABSTRACT

OBJECTIVE:

To evaluate the efficacy of NESTROFT (Naked Eye Single Tube Red Cell Osmotic Fragility Test) as a screening tool for detection of beta thalassemia trait.

DESIGN:

Prospective study.

SETTING:

Field camps in various parts of Gujarat and Maharashtra States.

METHODS:

A total of 2525 subjects were screened. NESTROFT, complete hemogram including red cell indices and calculation of Mentzer's Fraction (MF) and discriminant functions (DF1-4) were done in all subjects. HbA2 was performed in 830 initial subjects to compute sensitivity, specificity and predictive values for various parameters.

RESULTS:

NESTROFT (sensitivity 94.4%), as a single screening parameter was superior to any of the other evaluated parameters individually, besides being cost effective. Mean corpuscular volume (MCV) < 80 fl followed NESTROFT closely (sensitivity 93.7; p > 0.05). MCV < 75 fl had a significantly (p < 0.001) lower sensitivity (87.3%) in comparison to both of these parameters. In contrast, MF, DF1, DF2, DF3 and DF4 did not meet the requirements of a good screening test with sensitivity values of 66.2%, 54.9%, 47.2%, 64.1% and 55.6%, respectively. NESTROFT in combination with MCV < 80 fl proved 100% sensitive. However, the combination was not cost effective.

CONCLUSION:

NESTROFT is a sensitive, cost effective, rapid and reliable screening test for detection of beta thalassemia trait in a population.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Fragilidad Osmótica / Femenino / Humanos / Masculino / Niño / Tamizaje Masivo / Valor Predictivo de las Pruebas / Estudios Prospectivos / Sensibilidad y Especificidad / Adolescente Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje País/Región como asunto: Asia Idioma: Inglés Revista: Indian Pediatr Año: 1997 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Fragilidad Osmótica / Femenino / Humanos / Masculino / Niño / Tamizaje Masivo / Valor Predictivo de las Pruebas / Estudios Prospectivos / Sensibilidad y Especificidad / Adolescente Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio de tamizaje País/Región como asunto: Asia Idioma: Inglés Revista: Indian Pediatr Año: 1997 Tipo del documento: Artículo