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Hyalinizing trabecular adenoma--a case report with FNAC histologic, MIB-1 proliferative index and immunohistochemical findings.
Indian J Pathol Microbiol ; 1998 Oct; 41(4): 479-84
Artículo en Inglés | IMSEAR | ID: sea-73004
ABSTRACT
Hyalinizing trabecular adenoma is a recently described benign thyroid tumor, almost exclusively occurring in females. The morphological features of this entity overlap with both papillary and medullary carcinoma to varying extent. This, in turn, creates a situation of serious diagnostic pitfall particularly for a false positive diagnosis of papillary carcinoma in fine needle aspiration (FNA) cytology. False consideration of medullary carcinoma is also possible by the unwary especially if staining for Congo red and/or immunostaining for calcitonin is not resorted to. At histologic level, the distinctive architectural pattern is however of great help and thus poses a much lesser danger of misdiagnosis. We relate here our experience in a recently encountered case of hyalinizing trabecular adenoma and describe detailed FNA cytologic and histologic findings along with immunohistochemical profile using a panel of eight monoclonal antibodies. The tumor proliferative potential has also been assessed using MIB-1 (Ki-67) immunostaining. The various pros and cons of diagnostic pitfalls are discussed.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Glándula Tiroides / Biopsia con Aguja / Femenino / Humanos / Neoplasias de la Tiroides / Inmunohistoquímica / Carcinoma Papilar / Adenoma / División Celular / Carcinoma Medular Idioma: Inglés Revista: Indian J Pathol Microbiol Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Glándula Tiroides / Biopsia con Aguja / Femenino / Humanos / Neoplasias de la Tiroides / Inmunohistoquímica / Carcinoma Papilar / Adenoma / División Celular / Carcinoma Medular Idioma: Inglés Revista: Indian J Pathol Microbiol Año: 1998 Tipo del documento: Artículo