Antidermatophytic activity of allylamine derivatives.
Indian J Pathol Microbiol
;
1994 Oct; 37(4): 381-8
Artículo
en Inglés
| IMSEAR
| ID: sea-74152
ABSTRACT
The allylamine derivatives are a new class of synthetic antifungal agents. The antidermatophytic activity of the two main compounds, naftifine and terbinafine were compared in vitro with those of ketoconazole and itraconazole by agar dilution. Eighty eight clinical isolates of dematophytes comprising of Microsporum canis (50), M. audouinii (5), Trichophyton rubrum (6) T. mentagrophytes (5), T. violaceum (12), T. simii (5), T. verrucosum (1), T. soudanense (1), T. erinacie (1) and Epidermophyton floccosum (2) were tested. Terbinafine was found to be most active, inhibiting 68 of the 88 isolates at a concentration of 0.01 ug ml-1 and all at 0.1 ug ml. (Minimum inhibitory concentration - MIC range < or = 0.0001-0.1 ug ml-1). Naftifine inhibited 84 isolates at a concentration of 0.1 ug ml-1 and all at 0.5 ug ml-1 (MIC range 0.001-0.5 ug ml-1). Itraconazole required 0.1 ug ml-1 for inhibiting 50 isolates and 0.5 ug ml-1 for 85 isolates (MIC range 0.01-1 ug ml-1) whereas ketoconazole inhibited 71 isolates at 1 ug ml-1 and 87 at 2.5 ug ml-1 (MIC range 0.01-5 ug ml-1).
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pruebas de Sensibilidad Microbiana
/
Itraconazol
/
Arthrodermataceae
/
Alilamina
/
Cetoconazol
/
Antifúngicos
/
Naftalenos
Idioma:
Inglés
Revista:
Indian J Pathol Microbiol
Año:
1994
Tipo del documento:
Artículo
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