Role of immunophenotyping in characterisation of blast crisis of chronic myeloid leukemia--a study of 25 cases.
Indian J Pathol Microbiol
;
1996 Jan; 39(1): 13-7
Artículo
en Inglés
| IMSEAR
| ID: sea-74771
ABSTRACT
The blast cell populations of 25 patients of chronic myeloid leukemia in blast crisis (CML-BC) were studied for morphological, cytochemical and immunophenotypic features. The patients were divided into 6 broad groups based upon the pattern of surface marker positivity-myeloblastic, mixed myeloblastic, megakaryoblastic, mixed lineage, lymphoid and undifferentiated blast crisis. Myeloperoxidase (MPO), Sudan Black B (SBB) and Chloroacetate esterase (CAE) stains showed 100% specificity for the myelomonocytic lineage but the sensitivity was low. Periodic acid Schiff (PAS) stain was neither specific nor sensitive for the lymphoid lineage. Immunophenotyping as compared to morphologic and cytochemical assessment, was seen to be most useful for assigning a lineage to leukemic cells in CML-BC.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Fenotipo
/
Femenino
/
Humanos
/
Masculino
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Crisis Blástica
/
Inmunofenotipificación
/
Subgrupos de Linfocitos T
/
Adulto
/
Persona de Mediana Edad
Idioma:
Inglés
Revista:
Indian J Pathol Microbiol
Año:
1996
Tipo del documento:
Artículo
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