Role of FAB classification of acute leukemias in era of immunophenotyping.
Indian J Pathol Microbiol
;
2006 Oct; 49(4): 524-7
Artículo
en Inglés
| IMSEAR
| ID: sea-75280
ABSTRACT
French-American-British classification for leukemias had been widely accepted due to its objectiveness and good reproducibility. WHO classification of leukemias was formulated in 1997 with a purpose of further enhancing the objectivity. However, the requirement of cytogenetics and immunophenotyping makes it difficult for many countries like India to put WHO classification in routine use. This study was carried to know the effectiveness of FAB classification in an era of technical advancement. A retrospective analysis of all acute leukemias over a period of 2 years was done. Out of total of 469 cases of acute leukemias, 193 were diagnosed as Acute Lymphoblastic Leukemia (ALL), 200 as Acute Myeloid Leukemia (AML), and 76 cases diagnosed as Acute Leukemia, cytochemically undifferentiated. Hence, only 16% of all leukemias remained unclassifiable. Subclassification of AML cases revealed a much higher percentage of AML-M3, as compared to western literature. In conclusion, FAB classification, based on morphology and simple cytochemical stains, remains effective enough, although cytogenetics and immunophenotyping can add to diagnostic accuracy in some cases.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Humanos
/
Leucemia
/
Leucemia Mieloide
/
Niño
/
Preescolar
/
Enfermedad Aguda
/
Inmunofenotipificación
/
Adulto
/
Citogenética
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Estudios de evaluación
Idioma:
Inglés
Revista:
Indian J Pathol Microbiol
Año:
2006
Tipo del documento:
Artículo
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