Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts.
Indian J Pathol Microbiol
;
2004 Apr; 47(2): 298-301
Artículo
en Inglés
| IMSEAR
| ID: sea-75458
ABSTRACT
To determine if beta-2 microglobulin (beta2M) levels were elevated in our HIV infected patient population and if it could be used as a surrogate marker for disease progression. Thirty-eight HIV infected individuals and 26 age and sex-matched controls were studied. Measurement of CD4 cell count was carried out on a flowcytometer using anti-human CD4 monoclonal antibody and beta2M was measured by an enzyme immunoassay. Mean levels of HIV infected individuals were 1.29 +/- 0.52 mg/L and were significantly higher than 0.74 +/- 0.07 mg/L, the value of controls (p value <0.01). There was a negative correlation between CD4 counts and beta2M levels (r-value-0.79, p value <0.001). Beta2M levels in HIV infected individuals who have no opportunistic infection are elevated and these levels correlate with the CD4 counts. Beta2M can be used for the clinical follow-up of patients with HIV infection.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Femenino
/
Humanos
/
Masculino
/
Biomarcadores
/
Estudios de Casos y Controles
/
Infecciones por VIH
/
Microglobulina beta-2
/
Recuento de Linfocito CD4
/
Adulto
/
India
Tipo de estudio:
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Pathol Microbiol
Año:
2004
Tipo del documento:
Artículo
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