Effect of vitamin C deficiency and excess on the liver: a histopathological and biochemical study in guinea pigs fed normal or high cholesterol diet.
Indian J Pathol Microbiol
; 1990 Oct; 33(4): 307-13
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| ID: sea-75512
When guinea pigs were kept on a restricted vitamin C intake of only 0.5 mg daily, their serum ascorbic acid fell to 0.16 +/- 0.06 mg/d1 in 16 weeks as compared to 0.73 +/- 0.11 in control. This was associated with significant increase in liver cholesterol and triglycerides. When they were simultaneously challenged with a high cholesterol load, this fat accumulation was markedly exaggerated. The weight of the liver now increased by almost two-and-half times. Liver cholesterol rose to 12.90 +/- 2.63 mg/gm as compared to 3.23 +/- 0.56 mg/gm with low vitamin C alone. Histopathology showed marked distension and vacuolation of hepatocytes, focal necrosis and fibroplasia. Administration of excess vitamin C (100 mg daily) significantly countered these changes. The vitamin C-lipid relationship has important clinical bearings and liver could be an important site of vitamin C action.
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Asunto principal:
Tamaño de los Órganos
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Ácido Ascórbico
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Deficiencia de Ácido Ascórbico
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Triglicéridos
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Masculino
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Colesterol en la Dieta
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Colesterol
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Cobayas
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Hígado
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Animales
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En
Revista:
Indian J Pathol Microbiol
Año:
1990
Tipo del documento:
Article