Immunohistochemical localisation of carcinoembryonic antigen (CEA) in malignant epithelial ovarian tumours using monoclonal antibodies.

ABSTRACT

The localization of carcinoembryonic antigen (CEA) in malignant epithelial ovarian tumours was studied using immunohistochemistry. The tissue included in the study consisted of 38 ovarian cancers 14 mucinous adenocarcinomas, 23 serous adenocarcinomas and 1 endometroid carcinoma. Peroxidase-antiperoxidase staining technique using monoclonal antibodies to CEA was used on routinely fixed paraffin embedded tissues. CEA positivity was observed in all (100%) mucinous adenocarcinomas whereas only one case of serous cyst a denocarcinoma (4.3%) was weakly positive. The only case endometroid carcinoma encountered showed patchy CEA positivity.