Neuronal protection with magnesium.
Indian J Pediatr
;
2001 May; 68(5): 417-9
Artículo
en Inglés
| IMSEAR
| ID: sea-78431
ABSTRACT
Delayed neuronal death following hypoxic ischaemic insult is primarily mediated by the N-methyl D-aspartate (NMDA) receptor. The NMDA receptor antagonist MK 801, has been shown to limit neuronal death following hypoxic ischaemic injury but is too toxic to be used in the human neonate. Magnesium blocks the NMDA channel in a voltage dependent manner. Its administration after a simulated hypoxic ischaemic insult limits neurological damage in several animal models. The efficacy of magnesium in providing neuroprotection in the human neonate, however needs to be established in controlled clinical trials.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Asfixia Neonatal
/
Humanos
/
Recién Nacido
/
Maleato de Dizocilpina
/
Muerte Celular
/
Fármacos Neuroprotectores
/
Magnesio
/
Sulfato de Magnesio
/
Neuronas
Idioma:
Inglés
Revista:
Indian J Pediatr
Año:
2001
Tipo del documento:
Artículo
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