Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.
Indian J Pediatr
;
2006 Nov; 73(11): 985-8
Artículo
en Inglés
| IMSEAR
| ID: sea-79352
ABSTRACT
OBJECTIVE:
Pyruvate Kinase (PK) deficiency is the most common enzymopathy of the glycolytic pathway in erythrocytes. It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia. The aim of this study was to screen newborns in India for pyruvate kinase (PK) deficiency in relation to unconjugated hyperbilirubinemia.METHODS:
Laboratory investigations done included complete blood counts, reticulocyte counts, direct and indirect bilirubin, assay of G6PD and PK activity, ATP and 2,3 DPG levels. All variables were studied in 50-cord blood samples from normal deliveries and 218 neonates with hyperbilirubinemia.RESULTS:
7 of the 218 cases of neonatal jaundice were PK deficient with 30-40% reduction in PK activity. These cases also had a 3-4-fold increase in 2,3 DPGATP ratios, which is one of the additional indicators for PK deficiency. Six of the 7 infants had a severe clinical course.CONCLUSION:
This study shows that the prevalence of PK deficiency in Indian neonatal jaundice cases is 3.21%, which is relatively high. This emphasizes the need for screening neonatal hyperbilirubinemia cases in India for PK deficiency.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Piruvato Quinasa
/
Femenino
/
Humanos
/
Masculino
/
Recién Nacido
/
Eritrocitos
/
India
/
Ictericia Neonatal
/
Errores Innatos del Metabolismo
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Indian J Pediatr
Año:
2006
Tipo del documento:
Artículo
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