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Six-monthly de-worming in infants to study effects on growth.
Indian J Pediatr ; 2001 Sep; 68(9): 823-7
Artículo en Inglés | IMSEAR | ID: sea-81402
ABSTRACT

OBJECTIVE:

The study was conducted to assess the effectiveness of six monthly albendazole (ABZ) for improving the weight and height of preschool children when initiated at 0.5-1 year of age in populations with a high transmission rate of intestinal roundworm, Ascaris lumbricoides. It was a cluster randomized trial in the urban slums of Lucknow, North India.

METHODS:

Control children received 2 ml (1 ml to infants) of Vitamin A every six month whereas those in the ABZ areas received, in addition, 400 mg of ABZ suspension (Zentel, SKB) every six month. Sixty-three and sixty-one slum areas were randomized to albendazole (ABZ) or to control groups, respectively. Children aged 0.5-1 year were recruited in April 1996 and followed up for 1.5 years. Of 1022 children recruited from control and 988 from ABZ areas, the loss to follow-up at 1.5 year was 15.6% and 14.6% respectively. Mean (+/- SE) weight gain in Kg in control versus ABZ areas was 3.04 (0.03) versus 3.22 (0.03), (p = 0.01).

RESULTS:

After controlling for the presence of weight-for age z-score < -2.00 at enrollment in the ordinary least square's regression model, the extra weight gain in 1.5 years in those who received ABZ plus vitamin A was 0.13 Kg (95% CI 0.004 to 0.26 Kg., p value = 0.043) when compared to those who received only vitamin A; underweight children at enrollment benefiting more than the normal ones.

CONCLUSION:

It was concluded that there was an improvement in weight with six monthly ABZ over 1.5 years. However, a much larger trial would be needed to determine whether there is any net effect of improvement in weight on under five mortality rate.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ascariasis / Vitamina A / Estatura / Peso Corporal / Femenino / Humanos / Masculino / Trastornos de la Nutrición del Niño / Áreas de Pobreza / Albendazol Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Pediatr Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Ascariasis / Vitamina A / Estatura / Peso Corporal / Femenino / Humanos / Masculino / Trastornos de la Nutrición del Niño / Áreas de Pobreza / Albendazol Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico País/Región como asunto: Asia Idioma: Inglés Revista: Indian J Pediatr Año: 2001 Tipo del documento: Artículo