Vesicoureteric reflux deterioration in monozygotic twins.
Indian J Pediatr
;
2008 Mar; 75(3): 285-7
Artículo
en Inglés
| IMSEAR
| ID: sea-82559
ABSTRACT
Primary vesicoureteric reflux (VUR) is the most common inherited structural urinary tract disorder, conforming closely to autosomal dominant transmission. A pair of monozygotic siblings is described exhibiting a remarkably parallel clinical course. VUR grade II was diagnosed in girl A during urinary tract infection at the age of 2 yr; screening of her asymptomatic sister (girl B) revealed the same. Renal cortical scintigraphy unveiled unilateral hypo-dysplasia in both the twins. Despite trimethoprime-sulfamethoxazole prophylaxis, infection recurred in girl A after 7 months, while girl B had a first episode 2 months later that prompted regimen switch to nitrofurantoin. Follow-up at the age of 4 depicted bilateral reflux deterioration; an urodynamics study that followed revealed functional bladder instability in both girls and the oral antispasmodic oxybutynin was initiated with good results. Evaluation for reflux should be prompt in infants with urinary infection. Patient siblings display a higher relative reflux risk, being highest in identical twins. Heredity issues, the impact of age and dysfunctional voiding in the clinical course, and the contribution of nuclear medicine in VUR management are discussed.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Gemelos Monocigóticos
/
Urodinámica
/
Reflujo Vesicoureteral
/
Femenino
/
Humanos
/
Renografía por Radioisótopo
/
Preescolar
/
Antagonistas Muscarínicos
/
Radiofármacos
/
Ácido Dimercaptosuccínico de Tecnecio Tc 99m
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Indian J Pediatr
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS