NPHS2 mutations.
Indian J Pediatr
;
2008 Feb; 75(2): 135-8
Artículo
en Inglés
| IMSEAR
| ID: sea-83289
ABSTRACT
OBJECTIVE:
To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS).METHODS:
Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing.RESULTS:
NPHS2 mutations were evident in four patients (25%) who were bearing four novel mutations including two frame shift mutations (R238fs and P45fs) and two missense mutations (I136L and F216Y). There were no phenotypic or histological characteristics of patients bearing NPHS2 mutations, apart from the earlier onset of the disease, compared to those who were not bearing mutations.CONCLUSION:
NPHS2 mutations are prevalent in Egyptian children with non-familial SRNS and this may in part explain the less favorable prognosis reported in these patients.
Texto completo:
Disponible
Índice:
IMSEAR (Asia Sudoriental)
Asunto principal:
Pronóstico
/
Humanos
/
Marcadores Genéticos
/
Niño
/
Preescolar
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Estudios Transversales
/
Mutación del Sistema de Lectura
/
Polimorfismo Conformacional Retorcido-Simple
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
Indian J Pediatr
Año:
2008
Tipo del documento:
Artículo
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