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Serum TNF-alpha and free radical scavengers in neonatal septicemia.
Indian J Pediatr ; 1999 Jul-Aug; 66(4): 511-6
Artículo en Inglés | IMSEAR | ID: sea-83937
ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) and free radicals have been implicated in the pathogenesis of neonatal septicemia and its complications. This case control study was conducted between November 1996 to July 1997 to determine the levels of TNF-alpha and free radical scavengers viz. superoxide dismutase (SOD) and glutathione peroxidase (GPX) in the serum of 30 septic neonates and 20 healthy controls. Patients with neonatal sepsis registered significantly higher levels of TNF-alpha, SOD and GPX in comparison to controls (p < 0.05). The neonates with septic shock had five fold increase in TNF-alpha levels (2262 +/- 605.8 pg/ml) as compared to those without shock (738.8 +/- 728.8 pg/ml). There was no statistically significant difference in levels of antioxidant enzymes between neonates with shock and without shock. The levels of TNF-alpha and antioxidant enzymes were not affected by the type of organism isolated in blood culture.
Asunto(s)
Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Superóxido Dismutasa / Femenino / Humanos / Masculino / Recién Nacido / Estudios de Casos y Controles / Depuradores de Radicales Libres / Factor de Necrosis Tumoral alfa / Sepsis / Glutatión Peroxidasa Tipo de estudio: Estudio observacional Idioma: Inglés Revista: Indian J Pediatr Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: IMSEAR (Asia Sudoriental) Asunto principal: Superóxido Dismutasa / Femenino / Humanos / Masculino / Recién Nacido / Estudios de Casos y Controles / Depuradores de Radicales Libres / Factor de Necrosis Tumoral alfa / Sepsis / Glutatión Peroxidasa Tipo de estudio: Estudio observacional Idioma: Inglés Revista: Indian J Pediatr Año: 1999 Tipo del documento: Artículo